Archives for the month of: April, 2012

The Brotherhood of Man

Tearing each others’ hair
and stealing each others’ toys:
One Father whips them.

Even in the Next World

The mirror’s looking
for its basis. A kind of door,
Also a window.

Each and Every Sabbath

One person’s soul
burns like Shabbos candles. Others’:
Smell of cholent, mulch.

Nel Mezzo Del Cammin

Half way along now
lost on the Sefirah path.
I don’t see angels.

Buy It Today!

The dybbuk-golem
possesses you — then slays your
internal enemies.

About a contemporary Jewish leader

First ever rebbe
Who teaches his hasidim
The best way to hate.

When The Mind Rests

Leave off thinking, and
the Shechinah fills it in.
So what is the point?

Cross-posted to Baltimore Book Talk.

“I’m pretty grim for a comic poet,” remarked Ron Padgett after reading one of his more morbid pieces as this year’s guest of the Joshua Ringel reading series. Padgett’s work is permeated by the influence of his teacher Kenneth Koch, his gentle aphorisms and low-grade epiphanies.  ”Take out the trash/Love life,” Padgett writes in his How to Be Perfect, then disarms his own oracular tendencies with “Use exact change,” and even – elsewhere – “Don’t give advice.”

While Koch seems always to bounce back and forth between the poles of advice and aw-shucks, Padgett has an appetite for the metaphysical, even the memento-mori. “Don’t be afraid of anything beyond your control. Don’t be afraid, for instance, that the building will collapse as you sleep, or that someone you love will suddenly drop dead.” Grim indeed, and perhaps not comic to the sponsors of the series, in memory of a talented young man who died in a car accident in his 20s - himself a poetry student of Koch’s. But for all that, Padgett provided the right metaphysical aspect: engaging, friendly to the audience and their questions, and without an ounce of the preening self-regard that clings to many illustrious literary figures.

The fifteenth reader in the annual series (Koch was the first), Padgett was well received by those in attendance in the half-full auditorium of the Baltimore Museum of Art.  A successful career as a metaphysical comic poet might be worth aiming for, like something out of ancient philosophy. Walking out into the rainy afternoon after the event, one could sense in each Baltimore moment both the certainty of death and the calm comedy of self-effacement.

I hope to write regularly on doctors’ decision-making. This first installment concerns types of evidence-based studies. Later, I will talk about how and whether doctors actually use such evidence to make decisions.

There are a number of kinds of evidence-based advice which doctors can use to make decisions. The differences among them are instructive.

1. Individual journal articles. These can present findings from a single trial. The potential biases are multiple. Not all findings get published (publication bias – i.e. we never find out about the results which do not support the hypothesis). Many results are never reproduced. To quote one widely read study, “studies that report positive or significant results are more likely to be published and outcomes that are statistically significant have higher odds of being fully reported.” Some studies have to be retracted later by the journal which publishes them.

2. Reviews. These can be of many kinds.  A narrative review recounts in a summary form the findings of a number of articles. The summary is susceptible to bias from many factors: which articles are chosen, what emphases are given, which author is doing the review. For that reason, some people prefer a –

3. Systematic review. This combines research articles on a given topic according to strict definitions made a priori. Then the results from these individual articles are combined only if they are comparable, i.e. applying to the same population or disease. Some of the time individual results can be merged in a statistical way, called a meta-analysis. I work on a number of these; they have their own problems (the link is from an orthodontics journal but the issues are generally applicable). 

4. Guidelines. Using the above reviews, a group of experts, often physicians, draft official recommendations for a given disease, group of diseases, or use of a given medication or procedure. But guidelines are only as good as the evidence they are based on, the applicability of the guidelines to the particular question that is being considered — is the patient from the population that was studied? is the clinical condition the same? — and any bias that might have affected the results.

To take one example of a well-done review, the American Academy of Neurology and the American Headache Society recently published Evidence-based guideline update: Pharmacologic treatment for episodic migraine prevention in adults. Even such a guideline, however, comes with weaknesses. For some of these we can quote the authors: while good-quality evidence does support the effectiveness of certain medications for treating migraines, “evidence is unavailable to help the practitioner choose one therapy over another.” 

Another sort of weakness was also reported by these authors, but in a different way, in an often-ignored paragraph at the end of the article. For those that can’t read the small type, these are disclosures of possible conflicts of interest. Nearly all the authors have received honorariums from a number of pharmaceutical companies. I don’t think this completely obviates the recommendations, but it might if we look closely enough. This is why, to my way of thinking, any such guidelines need to be either free of conflict of interest or ensure balanced COIs within the writers.

Dr. Silberstein is on the advisory panel of and receives honoraria from AGA, Allergan, Amgen, Capnia, Coherex, Colucid, Cydex, GlaxoSmithKline, Lilly, MAP, Medtronic, Merck, Minster, Neuralieve, NINDS, NuPathe, Pfizer, St. Jude Medical, and Valeant. He is on the speakers’ bureau of and receives honoraria from Endo Pharmaceuticals, GlaxoSmithKline, and Merck. He serves as a consultant for and receives honoraria from Amgen and Novartis. His employer receives research support from AGA, Allergan, Boston Scientific, Capnia, Coherex, Endo Pharmaceuticals, GlaxoSmithKline, Lilly, MAP, Medtronic, Merck, NINDS, NuPathe, St. Jude Medical, and Valeant Pharmaceuticals. Dr. Holland (formerly Dr. Pearlman) receives consulting income from Map Pharmaceuticals and the American Headache Society and research support from Albert Einstein College of Medicine. Dr. Freitag has served on the scientific advisory boards of Zogenix Pharmaceuticals, Allergan Pharmaceuticals, Nautilus, MAP Pharmaceuticals, and Nupathe; has received travel expenses and or honoraria from GlaxoSmithKline, Zogenix, Merck, Nautilus, Allergan, Diamond Headache Clinic Research and Educational Foundation (not for profit), and the American Headache Society (travel). Dr. Freitag is a member of the Board of Directors of the National Headache Foundation. Dr. Dodick, within the past 3 years, serves on advisory boards and has consulted for Allergan, Alder, Pfizer, Merck, Coherex, Ferring, Neurocore, Neuralieve, Neuraxon, NuPathe Inc., MAP, SmithKlineBeecham, Boston Scientific, Medtronic, Inc., Nautilus, Eli Lilly & Company, Novartis, Colucid, GlaxoSmithKline, Autonomic Technologies, MAP Pharmaceuticals, Inc., Zogenix, Inc., Impax Laboratories, Inc., Bristol Myers Squibb, Nevro Corporation, Atlas, Arteaus, and Alder Pharmaceuticals. Within the past 3 years, Dr. Dodick has received funding for travel, speaking, or editorial activities from CogniMed, Scientiae, Intramed, SAGE Publishing, Lippincott Williams & Wilkins, Oxford University Press, Cambridge University Press, Miller Medical, Annenberg for Health Sciences; he serves as Editor-in-Chief and on the editorial boards of The NeurologistLancet Neurology, and Postgraduate Medicine; and has served as Editor-in-Chief of Headache Currents and as an Associate Editor of Headache; he receives publishing royalties for Wolff’s Headache, 8th edition (Oxford University Press, 2009) and Handbook of Headache (Cambridge University Press, 2010). Within the past 3 years, Dr. Dodick has received research grant support from Advanced Neurostimulation Systems, Boston Scientific, St Jude Medical, Inc., Medtronic, NINDS/NIH, Mayo Clinic. Dr. Argoff has served on a scientific advisory board for the Department of Defense and DSMB for the NIH; has received funding for travel and/or speaking and/or has served on a speakers’ bureau for Pfizer (King), Janssen (Pricara), Millennium Laboratories, Neurogesx, Forest Laboratories, Eli Lilly, Covidien, and Endo Pharmaceuticals; has received research support from Endo Pharmaceuticals, Forest Laboratories, Eli Lilly, Neurogesx, Pfizer, and SBRT funded by the NIH; and has received stock/stock options from Pfizer. Dr. Ashman is the Level of Evidence editor for Neurology and serves on the AAN Guideline Development Subcommittee. He reports no other disclosures. Full disclosures were provided at the time of Board approval. Go to Neurology.org for full disclosures.

 

Wall talks to wall. One has a clock, the other a window, the third a cupboard with bandages etcetera. The fourth a door that opens and closes a thousand times a day.

Chair is across from chair. Occasionally the one looking for care picks the wrong one to sit in, and there is a dance for two chairs and two people till the problem is sorted out.

Tile borders ceiling tile. There is nothing to look at, lying there, but ceiling, and after a while I begin to see faces, continents, games, riddles.

Beat head on wall. Stop.
How are you supposed to take
pity on yourself?

File:Tiferet postcard.jpg

Take Your Only…

Mine is a daughter.
The very same mountain, but
she’ll know what’s doing.

Pursuer of Peace
slips on his compromises
falls and breaks his neck.

 

Sunset’s loveliness
Exchanged now for the sunrise -
Just one loveliness.

Blindness comes from light.
From darkness – the eyes become
again light-ready.

Yom Haatzmaut

As long as heart beats-
there should be the effort, too
to make dreams better.

We’ve almost arrived

- finally – at the longed for
planned towards
middle.

In 2004, I laid out some ways in which I have tried to remember the Holocaust: narrative, history, and prayer. 

I saw a patient of mine this week: someone he loved died. He said, “I felt like I went to bed one day and got up the next day a different person.” 

I wonder whether he’ll be happy someday as that new person. Or if that new person, to be authentic, must always have that pain. If the latter is true, to make it better would be a lie. 

Creative Commons image by theilr

To Volcano, with esteem

From a scorching cra-
-ter, a curl of smoke points up,
up-up-up-upward!

The tree of the field

A bang. A bang.
Bang. A chop. A saw. The tree
doesn’t care to fall.

Waiting

Brilliant now, the
buried bones. But just wait for
what’s from the dry bones.

Or just zitsfleisch…

Wait forever, if
necessary, for the illed-
out moment. Amen.

Yom HaShoah

The bed/coffin swings
empty. Those that are made ash –
can they be buried?

Creation

So hot! Orange soda
– the Shechinah — bubbles
on ice cream. Shehakol.

Sefirah Style

The hair left to grow.
Animals: winter. In us
this estivation.

 

A few years ago, on my old blog, I posted a series of sefirah haikus. Here there are again, somewhat modified, for your counting pleasure. I will post seven of these weekly until Shavuot.  The Yiddish version is available on this blog, too, over on the other side of the mechtizah.

This first week’s sefirah is chesed.

חסד היום שגוע / אלפרד טניסון

Yellow, white to spite
the begrudging day. Do not
hold yourself back, now.

When I give, the I’s
not lessened but strengthened – when
I hold back, it falls.

I’m braggy about
my serious piety.
Prayer works with me.

But my love for him
did not demean him. He can
resist everything.

Under the throne of
glory, there’s a neon sign:
Danger! Do not touch!

Multiplicative
power floods every limit.
Death also begets.

With your two yetzers.
You say you have a thousand?
He has an Ain-Sof.

In a field
I’m not one of
the cows.
This is
always the case.
For all x not equal to me
I am not x.

More at qarrtsiluni.